Macromolecular recognition in the Protein Data Bank

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Macromolecular recognition in the Protein Data Bank

Crystal structures deposited in the Protein Data Bank illustrate the diversity of biological macromolecular recognition: transient interactions in protein-protein and protein-DNA complexes and permanent assemblies in homodimeric proteins. The geometric and physical chemical properties of the macromolecular interfaces that may govern the stability and specificity of recognition are explored in c...

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Fold-recognition detects an error in the Protein Data Bank

Determining the 3D-structure of a protein by means of X-ray crystallography, requires the fitting of the amino acid sequence into an electron-density map. This can be a difficult, time-consuming task if the map is of low resolution, showing little data for the side-chains. Here we show how fold recognition allowed us to detect an error in a recently deposited PDB entry, and propose a method tha...

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Large macromolecular complexes in the Protein Data Bank: a status report.

The growing number of large macromolecular complexes in the Protein Data Bank (PDB) has warranted a closer look at these structures. An overview of the types of molecules that form these large complexes is presented here. Some of the challenges at the PDB in representing, archiving, visualizing, and analyzing these structures are discussed along with possible means to overcome them.

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The Protein Data Bank

The Protein Data Bank [PDB; Berman, Westbrook et al. (2000), Nucleic Acids Res. 28, 235-242; http://www.pdb.org/] is the single worldwide archive of primary structural data of biological macromolecules. Many secondary sources of information are derived from PDB data. It is the starting point for studies in structural bioinformatics. This article describes the goals of the PDB, the systems in pl...

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ژورنال

عنوان ژورنال: Acta Crystallographica Section D Biological Crystallography

سال: 2006

ISSN: 0907-4449

DOI: 10.1107/s090744490603575x